Tesamorelin

Tesamorelin is a stabilised synthetic analogue of growth-hormone-releasing hormone (GHRH), corresponding to the full GHRH(1–44) sequence with a trans-3-hexenoic acid group added to the N-terminus. That modification resists enzymatic (DPP-IV) cleavage, giving it greater stability than native GHRH. It is studied in endocrine-signalling research and supplied by NOX as a lyophilised research reference material for research use only; the information here is educational and not guidance for any human, clinical or veterinary application.

Tesamorelin binds GHRH receptors on somatotroph cells in the anterior pituitary, which in research models stimulates growth-hormone synthesis and release and, downstream, IGF-1. Investigators use it to examine this GHRH-receptor signalling in laboratory and preclinical settings. The focus is mechanistic; as a NOX research reference material it is supplied for research use only and is not associated with any therapeutic use.

In the literature Tesamorelin is most often referenced in work on the GHRH-to-growth-hormone axis and its downstream effects, including preclinical studies that examine visceral adipose tissue. The emphasis is on receptor signalling and mechanism rather than any applied outcome. As a NOX research reference material, Tesamorelin is supplied for research use only and is not associated with any therapeutic use.

Lyophilised Tesamorelin is supplied as a sealed, freeze-dried powder and is generally kept frozen and away from light, typically stored at around -20°C for long-term stability, while for shorter periods it can be kept in the fridge at 2–8°C. Keeping the vial sealed limits moisture uptake and helps preserve the dry material. This describes general laboratory handling of lyophilised research compounds and is provided for research use only, not as guidance for any other use.

Bacteriostatic water is commonly used to reconstitute lyophilised research compounds because the small amount of benzyl alcohol it contains helps limit microbial growth in a multi-use vial. It simply dissolves the freeze-dried powder into a liquid so the material can be handled in the laboratory. Reconstitution is performed strictly within a research context; Tesamorelin is supplied by NOX for research use only.

Once reconstituted, Tesamorelin is in solution and generally less stable than the dry powder, so the liquid is typically kept in the fridge at 2–8°C and protected from light. Researchers usually prepare only what a study requires and record the reconstitution date. This reflects general laboratory handling of reconstituted research materials and is offered for research-use-only context, not as guidance for human or veterinary use.

Tesamorelin is supplied as a lyophilised powder in 5 mg and 10 mg. The stated strength is the mass of compound sealed in the vial before reconstitution; the working concentration depends on the volume of solvent a researcher adds during preparation. All presentations are research reference materials supplied for research use only.

Yes. Tesamorelin is supplied by NOX strictly as a research reference material for laboratory and analytical use. It is not a medicinal product, food, cosmetic or veterinary product, and nothing in these answers should be read as guidance for human or animal use. All information here is provided for educational and research context only.