MOTS-c

MOTS-c is a 16-amino-acid mitochondrial-derived peptide, its sequence is encoded within the mitochondrial 12S ribosomal RNA gene rather than the nuclear genome. This unusual origin, and its role as a signalling peptide that circulates to metabolic tissues, is why it is widely referenced in metabolic-regulation research. NOX supplies MOTS-c lyophilised for research use only; the information here is educational and not guidance for any human, clinical or veterinary use.

Under metabolic stress MOTS-c is reported to translocate to the nucleus and activate AMPK, the cell's master metabolic sensor, in part by modulating the folate–methionine cycle, a profile that leads the literature to describe it as "exercise-mimetic". Investigators study these pathways in cell and preclinical models. This is educational mechanism context; MOTS-c is a research reference material supplied for research use only.

MOTS-c is most often examined in cellular-metabolism and energy-homeostasis research, glucose uptake, insulin sensitivity and diet-induced obesity models, using cell and preclinical systems that focus on mechanism rather than any applied outcome. As a NOX research reference material, MOTS-c is supplied for research use only and carries no medical claim.

Lyophilised MOTS-c is supplied as a sealed, freeze-dried powder and is generally kept frozen and away from light, typically stored at around -20°C for long-term stability, while for shorter periods it can be kept in the fridge at 2–8°C. Keeping the vial sealed limits moisture uptake and helps preserve the dry material. This describes general laboratory handling of lyophilised research compounds and is provided for research use only, not as guidance for any other use.

Bacteriostatic water is commonly used to reconstitute lyophilised research compounds because the small amount of benzyl alcohol it contains helps limit microbial growth in a multi-use vial. It simply dissolves the freeze-dried powder into a liquid so the material can be handled in the laboratory. Reconstitution is performed strictly within a research context; MOTS-c is supplied by NOX for research use only.

Once reconstituted, MOTS-c is in solution and generally less stable than the dry powder, so the liquid is typically kept in the fridge at 2–8°C and protected from light. Researchers usually prepare only what a study requires and record the reconstitution date. This reflects general laboratory handling of reconstituted research materials and is offered for research-use-only context, not as guidance for human or veterinary use.

Lyophilisation freeze-dries the material into a dry powder that is considerably more stable than a solution and tolerates storage and shipping far better. This is why research compounds such as MOTS-c are supplied lyophilised and reconstituted only when a study requires. The description is educational; the material is supplied strictly for research use only.

MOTS-c is supplied as a lyophilised powder in 10 mg. The stated strength is the mass of compound sealed in the vial before reconstitution; the working concentration depends on the volume of solvent a researcher adds during preparation. All presentations are research reference materials supplied for research use only.

Yes. MOTS-c is supplied by NOX strictly as a research reference material for laboratory and analytical use. It is not a medicinal product, food, cosmetic or veterinary product, and nothing in these answers should be read as guidance for human or animal use. All information here is provided for educational and research context only.